Article
CohortDiagnostics: Phenotype evaluation across a network of observational data sources using population-level characterization.
PloS one - 1 Jan 2025
Rao Gowtham A, Shoaibi Azza, Makadia Rupa, Hardin Jill, Swerdel Joel, Weaver James, Voss Erica A, Conover Mitchell M, Fortin Stephen, Sena Anthony G, Knoll Chris, Hughes Nigel, Gilbert James P, Blacketer Clair, Andryc Alan, DeFalco Frank, Molinaro Anthony, Reps Jenna, Schuemie Martijn J, Ryan Patrick B
Abstract excerpt
OBJECTIVE: This paper introduces a novel framework for evaluating phenotype algorithms (PAs) using the open-source tool, Cohort Diagnostics. MATERIALS AND METHODS: The method is based on several diagnostic criteria to evaluate a patient cohort returned by a PA. Diagnostics include estimates of incidence rate, index date entry code breakdown, and prevalence of all observed clinical events prior to, on, and after...
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