Using whole genome scores to compare three clinical phenotyping methods in complex diseases.

Abstract excerpt

Genome-wide association studies depend on accurate ascertainment of patient phenotype. However, phenotyping is difficult, and it is often treated as an afterthought in these studies because of the expense involved. Electronic health records (EHRs) may provide higher fidelity phenotypes for genomic research than other sources such as administrative data. We used whole genome association models to evaluate...

Topics

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• Algorithms
• Disease
• Electronic Health Records
• Genome-Wide Association Study
• Multifactorial Inheritance