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Molecular mechanisms of the viral encoded chaperone 100K in capsid folding and assembly of adenovirus

29 Apr 2025

Abstract excerpt

Adenovirus is an icosahedral, non-enveloped DNA virus that infects humans and other animals. The capsid of adenovirus is mainly assembled by the major capsid protein hexon. Folding and assembly of hexon require the viral encoded chaperone 100K, of which the detailed structure and chaperoning mechanism remain unknown. Here, we report the cryoEM structure of 100K in complex with a pre-mature hexon trimer. The...

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PMID: 40301360
DOI: 10.1038/s41467-025-59301-4

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