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Sex differences in cerebrospinal fluid proteomics of patients with restless legs syndrome

26 Apr 2025

Abstract excerpt

STUDY OBJECTIVES: The pathobiology of restless legs syndrome (RLS) remains poorly understood, complicating effective treatment. This observational cross-sectional study aimed to identify a cerebrospinal fluid proteomic signature of RLS and to explore sex-specific differences in cerebrospinal fluid proteomics. METHODS: Cerebrospinal fluid samples were collected from 22 untreated RLS patients and 18 controls,...

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PMID: 40289925
DOI: 10.1093/sleep/zsaf112

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