Article
Targeted DNA and RNA Sequencing of Paired Urothelial and Squamous Bladder Cancers Reveals Discordant Genomic and Transcriptomic Events and Unique Therapeutic Implications.
European urology - 1 Dec 2018
Hovelson Daniel H, Udager Aaron M, McDaniel Andrew S, Grivas Petros, Palmbos Phillip, Tamura Shuzo, Lazo de la Vega Lorena, Palapattu Ganesh, Veeneman Brendan, El-Sawy Layla, Sadis Seth E, Morgan Todd M, Montgomery Jeffrey S, Weizer Alon Z, Day Kathleen C, Neamati Nouri, Liebert Monica, Keller Evan T, Day Mark L, Mehra Rohit, Tomlins Scott A
Abstract excerpt
BACKGROUND: Integrated molecular profiling has identified intrinsic expression-based bladder cancer molecular subtypes. Despite frequent histological diversity, robustness of subtypes in paired conventional (urothelial) and squamous components of the same bladder tumor has not been reported. OBJECTIVE: To assess the impact of histological heterogeneity on expression-based bladder cancer subtypes. DESIGN, SETTING,...
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