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Emergence of transferable daptomycin resistance in Gram-positive bacteria

26 Apr 2025

Abstract excerpt

Daptomycin (DAP) is a last-resort antibiotic to treat infections by multiresistant Gram-positive pathogens, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci. DAP resistance and clinical treatment failure has been associated with adaptive chromosomal mutations, but so far not with transmissible resistance traits. Here we report for the first time an acquired DAP-R...

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PMID: 40287593
DOI: 10.1038/s44259-025-00109-z

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