Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Integrated multi-omics analysis reveals the functional and prognostic significance of lactylation-related gene PRDX1 in breast cancer

4 Apr 2025

Abstract excerpt

Background: Breast cancer (BRCA) is a significant threat to women's health worldwide, and its progression is closely associated with the tumor microenvironment and gene regulation. Lactylation modification, as a key epigenetic mechanism in cancer biology, has not yet been fully elucidated in the context of BRCA. This study examines the regulatory mechanisms of lactylation-related genes (LRGs), specifically PRDX1,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Clusterin in disease pathology
Share to Ferroptosis and cancer prognosis
Share to GDF15 and Related Biomarkers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40256656
DOI: 10.3389/fmolb.2025.1580622

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Integrated multi-omics analysis reveals the functional and prognostic significance of lactylation-related gene PRDX1 in breast cancerPMID 40256656Read ↗

Dissecting the Impact of Lactylation on Breast Cancer Prognosis and Its Underlying Mechanisms by Combining Single-Cell and Spatial Transcriptomics TechnologiesSemantic proximity Read ↗

Comprehensive analysis of the associations of LOXL1-4 with prognosis and immune infiltration in breast cancerSemantic proximity Read ↗

Identification of a novel immune-related gene signature by single-cell and bulk sequencing for the prediction of the immune landscape and prognosis of breast cancerSemantic proximity Read ↗

Lactylation-related gene signature for prognostic prediction and immune infiltration analysis in breast cancerSemantic proximity Read ↗

Integration of TWAS with single-cell and spatial transcriptomics identifies TLR1 as a susceptibility gene and therapeutic target in the breast cancer tumor microenvironment.Semantic proximity Read ↗

Integrating RNA-seq and scRNA-seq to explore the prognostic features and immune landscape of exosome-related genes in breast cancer metastasisSemantic proximity Read ↗

Decoding the Tumor-Suppressive Landscape of SCARA5: A Network-Based Analysis Linking Lipid Metabolism and Immune Regulation in Breast CancerSemantic proximity Read ↗

Differential chromatin accessibility and transcriptional dynamics define breast cancer subtypes and their lineagesSemantic proximity Read ↗

Human Tumor-Associated Macrophage and Monocyte Transcriptional Landscapes Reveal Cancer-Specific Reprogramming, Biomarkers, and Therapeutic TargetsSemantic proximity Read ↗

Uncovering immune cell-associated genes in breast cancer: based on summary data-based Mendelian randomized analysis and colocalization study.Semantic proximity Read ↗

Identification of Lysine lactylation (kla) -related lncRNA signatures using XGBoost to predict prognosis and immune microenvironment in breast cancer patientsSemantic proximity Read ↗

Unveiling the key mechanisms of FOLR2+ macrophage-mediated antitumor immunity in breast cancer using integrated single-cell RNA sequencing and bulk RNA sequencingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.