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Article

Association between gynecological cancers and female infertility: insights from bidirectional Mendelian randomization analysis.

BMC women's health - 18 Apr 2025

Li Jifeng, Zeng Yifei, Zhang Dongxiao

Abstract excerpt

PURPOSE: In recent years, research interest in the potential link between female infertility (FI) and gynecological cancer (GC), including ovarian cancer (OC), endometrial cancer (EC), cervical cancer (CC), and breast cancer (BC), has grown, yet findings remain inconclusive. This study aims to explore the causal relationship between FI and GC using bidirectional two-sample Mendelian randomization (MR) analyses,...

Read the complete abstract on PubMed

Topics

Humans
Female
Mendelian Randomization Analysis
Infertility, Female
Genome-Wide Association Study
Genital Neoplasms, Female

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Endometrial Neoplasms

Breast Neoplasms

Genetic Predisposition to Disease

Source

Open in PubMed Open full text

Identifiers

PMID: 40251594
DOI: 10.1186/s12905-025-03729-9
PMCID: PMC12007144

Genes

GC

Provenance

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