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Article

Causal Association Between Female Infertility and Circulating Immune Cells: A Bidirectional Mendelian Randomization Study.

American journal of reproductive immunology (New York, N.Y. : 1989) - 1 Mar 2025

Zhou Xuan, Fang Yu-Xuan, Ma Li-Ya, Zhang Da-Wei, Yao Man-Man

Abstract excerpt

BACKGROUND: Female infertility (FI) is a global health issue. The etiology remains incompletely understood, but immunologic factors play important roles. This study aims to elucidate the causal association between FI and immune cells (ICs) via Mendelian randomization (MR) analysis. METHODS: The MR analyses employ genetic variants as instrumental variables to evaluate exposure's causal impact on outcomes. In this...

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Share to CD4 gene
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Infertility, Female

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Share to Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 39998311
DOI: 10.1111/aji.70061

Genes

CD27
CD28
CD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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