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The glucose metabolism reprogramming of yak Sertoli cells under hypoxia is regulated by autophagy

18 Apr 2025

Abstract excerpt

Hypoxia often has negative effects on testis development and spermatogenesis of mammals. Plateau yaks have lived in the hypoxia environment for generations, but have ensured testicular function, which is closely related to their unique hypoxia response mechanism. Glucose metabolic reprogramming is an important way for cells to respond to stressful environments, especially the metabolite lactate, which is the...

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PMID: 40251498
DOI: 10.1186/s12864-025-11497-x

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