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Article

Genetic Study of HGF-MET Signaling Pathway in Primary Lymphedema Patients: Supporting Evidence for Loss of Function Variants in HGF.

Lymphology - 1 Jan 2024

Kozacikova R, Veselenyiova D, Gelanova V, Belanova I, Bonetti G, Kaftalli J, Maltese P E, Macchia A, Micheletti C, Donato K, Ferrari L, Miertus S, Miertus J, Ricci M, Cestari M, Michelini Si, Michelini Se, Cecchin S, Bertelli M, Michelini Sa

Abstract excerpt

The lymphatic system is composed of lymphatic vessels that connect lymphatic organs and play a critical role in draining lymph fluid from the intracellular environment. Disruptions in this system can lead to defects in lymphatic development and lymphedema which is characterized by chronic inflammation and fluid accumulation in tissues, finally resulting in swelling, pain, and fibrosis. If caused by genetic...

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Aged
CBL gene
Genetic Predisposition to Disease
Hepatocyte Growth Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Loss of Function Mutation

Proto-Oncogene Proteins c-met

Signal Transduction

Source

Identifiers

PMID: 40245437

Genes

HGF
MET
CBL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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