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Article

Polaris: Polarization of ancestral and derived polymorphic alleles for inferences of extended haplotype homozygosity in human populations.

Bioinformatics (Oxford, England) - 2 Jun 2025

Lisi Alessandro, Campbell Michael C

Abstract excerpt

SUMMARY: Statistical methods that measure the extent of haplotype homozygosity on chromosomes have been highly informative for identifying episodes of recent selection. For example, the integrated haplotype score (iHS) and the extended haplotype homozygosity (EHH) statistics detect long-range haplotype structure around derived and ancestral alleles indicative of classic and soft selective sweeps, respectively....

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Topics

Haplotypes
Humans
Alleles
Software
Homozygote
Genetics, Population
Polymorphism, Genetic

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Identifiers

PMID: 40221866
DOI: 10.1093/bioinformatics/btaf171
PMCID: PMC12199141

Genes

MCM6

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