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Naringin promotes osteoblast differentiation and ameliorates osteoporosis in ovariectomized mice

12 Apr 2025

Abstract excerpt

This study aimed to investigate the anti-osteoporotic mechanisms of naringin in osteoblasts and mice. In vitro, MC3T3-E1 cells were treated with naringin to detect cell proliferation, alkaline phosphatase (ALP) activity, and calcified nodule formation. Western blot was used to analyze the expression of osteogenic markers (OPN, COL1A1, RUNX2) and Wnt/β-catenin pathway proteins (Wnt3a, β-catenin). In vivo,...

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PMID: 40221578
DOI: 10.1038/s41598-025-97217-7

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