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Article

Alterations in genomic features and the tumour immune microenvironment predict immunotherapy outcomes in advanced biliary tract cancer patients.

British journal of cancer - 1 Jun 2025

Huang Chenjun, Qiu Zhiquan, Huang Honglian, Xiao Xiao, Du Fei, Ji Jun, Xu Xuewen, Jiang Xiaoqing, Wang Ying, Gao Chunfang

Abstract excerpt

BACKGROUND: The response to immunotherapy is limited in advanced biliary tract cancer (BTC). Response prediction is a serious challenge in the clinic. METHODS: This study included 60 patients with advanced BTC who received anti-PD-1 treatment. Among these patients, 30 were subjected to 520 gene panel sequencing, and 50 were subjected to multiplex circulating cytokine testing. The entropy and mutation features...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40211026
DOI: 10.1038/s41416-025-03011-7
PMCID: PMC12119827

Genes

BTC
NRAS
TP53
APC
CXCL10
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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