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KRAS mutations disrupt interactions between CD8+ T cells and antigen-presenting cells in the tumor microenvironment of biliary tract cancer.

International immunology - 1 Apr 2026

Terasaki Fumihiro, Kumagai Shogo, Fukuda Akito, Tanaka Yosuke, Irie Takuma, Ito Sachiko, Yamada Mihoko, Onoe Shunsuke, Mizuno Takashi, Kokuryo Toshio, Koyama Shohei, Karube Kennosuke, Nishikawa Hiroyoshi, Ebata Tomoki

Abstract excerpt

Biliary tract cancer (BTC) exhibits a poor prognosis and limited responses to current therapeutic strategies. While surgical resection followed by adjuvant S-1 therapy is the standard curative treatment for BTC, long-term postoperative remission is hardly achieved. Therefore, more effective perioperative strategies are urgently needed. Here, we show that an immune-cold tumor microenvironment (TME) in KRAS-mutated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41186264
DOI: 10.1093/intimm/dxaf065

Genes

BTC
KRAS
APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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