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[Clinical phenotype and gene mutation analysis of 12 patients with hereditary protein C deficiency in different families].

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi - 14 Jan 2022

Xu Q Y, Yang L L, Xie H X, Jin Y H, Li X L, Zhou X X, Liu M N, Wang M S

Abstract excerpt

Objective: To investigate the molecular pathogenesis and clinical features of unrelated 12 patients with inherited coagulation protein C (PC) deficiency in Chinese population. Methods: The PC activity (PC:A) and PC antigen (PC:Ag) were detected by chromogenic substrate and enzyme linked immunosorbent assay, respectively. The nine exons and flanking sequences of the protein C (PROC) gene were amplified by...

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Identifiers

PMID: 35231991
DOI: 10.3760/cma.j.issn.0253-2727.2022.01.008
PMCID: PMC8980666

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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