Recent emergence of cephalosporin-resistant Salmonella Typhi in India due to the endemic clone acquiring IncFIB(K) plasmid encoding bla CTX-M-15 gene.

doi:10.1128/spectrum.00875-24

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Recent emergence of cephalosporin-resistant Salmonella Typhi in India due to the endemic clone acquiring IncFIB(K) plasmid encoding bla CTX-M-15 gene.

Microbiology spectrum - 6 May 2025

Thirumoorthy Tharani Priya, Jacob Jobin John, Velmurugan Aravind, Teekaraman Monisha Priya, Shah Bhavini, Iyer Veena, Maheshwari Geeti, Trivedi Urmi, Shah Anand, Patel Pooja, Gaigawale Anushree, M Yesudoss, Sathya Narayanan Pavithra, Mutreja Ankur, Carey Megan, John Jacob, Kang Gagandeep, Veeraraghavan Balaji

Abstract excerpt

The emergence and spread of Salmonella Typhi (S. Typhi) resistant to third-generation cephalosporins is a serious global health concern. In this study, we genomically characterized 142 cephalosporin-resistant S. Typhi strains isolated from India. Comparative genome analysis revealed the emergence of a new clone of ceftriaxone-resistant S. Typhi harboring three plasmids of the incompatibility groups IncFIB(K),...

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PMID: 40208005
DOI: 10.1128/spectrum.00875-24
PMCID: PMC12054180

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