Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Bronchopulmonary dysplasia: signatures of monocyte-macrophage reactivity and tolerance define novel placenta-lung endotypes.

Pediatric research - 1 Dec 2025

Mestan Karen K, Sharma Abhineet M, Lazar Sarah, Pandey Sonalisa, Parast Mana M, Laurent Louise C, Prince Lawrence S, Sahoo Debashis

Abstract excerpt

BACKGROUND: Bronchopulmonary dysplasia (BPD) is a complex disease involving aberrant immune responses across the lifespan, but these mechanisms are challenging to follow in human infants. Leveraging novel Signatures of Macrophage Reactivity and Tolerance (SMaRT), we hypothesized that distinct profiles of immune cell polarization in blood and lung are associated with BPD. METHODS: Published transcriptomic datasets...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bronchopulmonary Dysplasia
Share to Fetal Blood

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immune Tolerance

Share to Macrophages

Share to Macrophages, Alveolar

Share to Monocytes

Share to Placenta

Source

Open in PubMed Open full text

Identifiers

PMID: 40175585
DOI: 10.1038/s41390-025-04025-w
PMCID: PMC12335971

Genes

IMPACT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Bronchopulmonary dysplasia: signatures of monocyte-macrophage reactivity and tolerance define novel placenta-lung endotypes.PMID 40175585Read ↗

Infants with evolving bronchopulmonary dysplasia demonstrate monocyte-specific expression of IL-1 in tracheal aspiratesSemantic proximity Read ↗

Transcriptional profiling of lung macrophages identifies a predictive signature for inflammatory lung disease in preterm infantsSemantic proximity Read ↗

Mapping fetal myeloid differentiation in airway samples from premature neonates with single-cell profilingSemantic proximity Read ↗

Single‐cell RNA sequencing of peripheral blood mononuclear cells from bronchopulmonary dysplasiaSemantic proximity Read ↗

Macrophage phenotype is associated with disease severity in preterm infants with chronic lung disease.Semantic proximity Read ↗

Paired Airway and Blood Multiomics Defines Coordinated Immune Adaptation Across the Airway–Blood Axis in Preterm InfantsSemantic proximity Read ↗

Toward precision for bronchopulmonary dysplasia: Moving past current definitions.Semantic proximity Read ↗

Lymphocyte-Specific Biomarkers Associated With Preterm Birth and Bronchopulmonary DysplasiaSemantic proximity Read ↗

Prenatal Development and Function of Human Mononuclear PhagocytesSemantic proximity Read ↗

Lymphocyte-Specific Biomarkers Associated with Preterm Birth and Bronchopulmonary DysplasiaSemantic proximity Read ↗

Prospective epigenome and transcriptome analyses of cord and peripheral blood from preterm infants at risk of bronchopulmonary dysplasiaSemantic proximity Read ↗

Systems-Level Insights into Bronchopulmonary Dysplasia from Meta-Analysis of Genome- Scale StudiesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.