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Insights into protection against Mycobacterium tuberculosis infection: time to officially confirm another phenotype?

31 Mar 2025

Abstract excerpt

Immune correlates of protection against infection with Mycobacterium tuberculosis (Mtb) remain elusive. In this issue of the JCI, Dallmann-Sauer and authors demonstrate that lack of tuberculin skin test (TST) and interferon γ release assay (IGRA) conversion among people with HIV despite years-long Mtb exposure is associated with alveolar lymphocytosis, including specific poly-cytotoxic T cells, and M1-type...

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PMID: 40166935
DOI: 10.1172/jci191423

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