Article
Early clearance of Mycobacterium tuberculosis: a new frontier in prevention.
Immunology - 1 Apr 2014
Verrall Ayesha J, Netea Mihai G, Alisjahbana Bachti, Hill Philip C, van Crevel Reimout
Abstract excerpt
Early clearance (EC) is the successful eradication of inhaled Mycobacterium tuberculosis before an adaptive immune response develops. Evidence for EC comes from case contact studies that consistently show that a proportion of heavily exposed individuals do not develop M. tuberculosis infection. Further support for the existence of this phenotype comes from genetic loci associated with tuberculin reactivity. In...
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