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Article

An analytical screening platform to differentiate acute and prolonged exposures of per- and polyfluoroalkyl substances on invasive cellular phenotypes.

Toxicological sciences : an official journal of the Society of Toxicology - 1 Jun 2025

Lidgett Ryan A, Miranda Buzetta Abel A, Baker J Ian, Dang Pearl, Oldenburg Amy L, Lockett Matthew R

Abstract excerpt

Per- and polyfluoroalkyl substances (PFAS) are "forever chemicals" and pervasive environmental contaminants associated with cancer. Epidemiological studies found that an increased incidence of hormone-sensitive breast cancer is correlated with PFAS exposure. Cell-based assays provide a well-controlled experimental platform to quantify cellular responses as a function of exposure. Given the nearly 15,000 known...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40156146
DOI: 10.1093/toxsci/kfaf044
PMCID: PMC12118960

Genes

PFAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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