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The effects of perfluorooctanoic acid on breast cancer metastasis depend on the phenotypes of the cancer cells: An in vivo study with zebrafish xenograft model.

Environmental pollution (Barking, Essex : 1987) - 1 Dec 2024

Huang Chi, Murgulet Ioana, Liu Linda, Zhang Mona, Garcia Kaitlin, Martin Leisha, Xu Wei

Abstract excerpt

Per- and polyfluorinated substances (PFAS) have been associated with numerous human diseases. Recent in vitro studies have implicated the association of PFAS with an increased risk of breast cancer in humans. This study aimed to assess the toxic effects of PFAS during the development of human breast cancer using a zebrafish xenograft model. Perfluorooctanoic acid (PFOA) was used as a PFAS chemical of interest for...

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PMID: 39293659
DOI: 10.1016/j.envpol.2024.124975

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