Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Proapoptotic Bcl-2 inhibitor as potential host directed therapy for pulmonary tuberculosis

27 Mar 2025

Abstract excerpt

Mycobacterium tuberculosis establishes within host cells by inducing anti-apoptotic Bcl-2 family proteins, triggering necrosis, inflammation, and fibrosis. Here, we demonstrate that navitoclax, an orally bioavailable, small-molecule Bcl-2 inhibitor, significantly improves pulmonary tuberculosis (TB) treatments as a host-directed therapy. Addition of navitoclax to standard TB treatments at human equipotent dosing...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chronic Lymphocytic Leukemia Research
Share to Mycobacterium research and diagnosis
Share to Tuberculosis Research and Epidemiology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40148277
DOI: 10.1038/s41467-025-58190-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Proapoptotic Bcl-2 inhibitor as potential host directed therapy for pulmonary tuberculosisPMID 40148277Read ↗

Role of apoptosis and autophagy in tuberculosisSemantic proximity Read ↗

Different modalities of host cell death and their impact on <i>Mycobacterium tuberculosis</i> infectionSemantic proximity Read ↗

Host-Directed Therapeutics for Tuberculosis: Can We Harness the Host?Semantic proximity Read ↗

Macrophage Apoptosis in TuberculosisSemantic proximity Read ↗

PPARγ is critical for Mycobacterium tuberculosis induction of Mcl-1 and limitation of human macrophage apoptosisSemantic proximity Read ↗

Macrophage and T lymphocyte apoptosis during experimental pulmonary tuberculosis: their relationship to mycobacterial virulenceSemantic proximity Read ↗

Living on the Edge: Inhibition of Host Cell Apoptosis by <i>Mycobacterium Tuberculosis</i>Semantic proximity Read ↗

Regulatory role and mechanism of the inhibition of the Mcl-1 pathway during apoptosis and polarization of H37Rv-infected macrophages.Semantic proximity Read ↗

Leishmania donovani-Induced Increase in Macrophage Bcl-2 Favors Parasite SurvivalSemantic proximity Read ↗

Vitamin C inhibits apoptosis in THP‑1 cells in response to incubation with Mycobacterium tuberculosisSemantic proximity Read ↗

Mycobacterium tuberculosis nuoG Is a Virulence Gene That Inhibits Apoptosis of Infected Host CellsSemantic proximity Read ↗

ESX-1-induced apoptosis during mycobacterial infection: to be or not to be, that is the questionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.