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Article

Regulatory role and mechanism of the inhibition of the Mcl-1 pathway during apoptosis and polarization of H37Rv-infected macrophages.

Medicine - 16 Oct 2020

Han Ling, Lu Yang, Wang Xiaofang, Zhang Shujun, Wang Yingzi, Wu Fang, Zhang Wanjiang, Wang Xinmin, Zhang Le

Abstract excerpt

BACKGROUND: Myeloid cell leukemia-1 (Mcl-1) plays an important role in the clearance of Mycobacterium tuberculosis (MTB) infection. It has the effect of anti-apoptosis, protecting macrophages that have engulfed pathogens and preventing pathogen clearance. Meanwhile, the MAPK signaling pathway plays a significant role in regulating Mcl-1 expression during tuberculosis infection. In the case of latent infection and...

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PMID: 33080678
DOI: 10.1097/MD.0000000000022438
PMCID: PMC7572003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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