Article
Running a genetic stop sign accelerates oxygen metabolism and energy production in horses.
Science (New York, N.Y.) - 28 Mar 2025
Castiglione Gianni M, Chen Xin, Xu Zhenhua, Dbouk Nadir H, Bose Anamika A, Carmona-Berrio David, Chi Emiliana E, Zhou Lingli, Boronina Tatiana N, Cole Robert N, Wu Shirley, Liu Abby D, Liu Thalia D, Lu Haining, Kalbfleisch Ted, Rinker David, Rokas Antonis, Ortved Kyla, Duh Elia J
Abstract excerpt
Horses are among nature's greatest athletes, yet the ancestral molecular adaptations fueling their energy demands are poorly understood. Within a clinically important pathway regulating redox and metabolic homeostasis (NRF2/KEAP1), we discovered an ancient mutation-conserved in all extant equids-that increases mitochondrial respiration while decreasing tissue-damaging oxidative stress. This mutation is a de novo...
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