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Article

Cardamom synergizes with cisplatin against human osteosarcoma cells by mTOR-mediated autophagy

26 Mar 2025

Abstract excerpt

Cisplatin (DDP), a frontline chemotherapeutic agent in osteosarcoma (OS) treatment, is frequently paired with other compounds to enhance its therapeutic potency. Cardamom (CAR), a natural flavonoid, exhibits significant inhibitory effects on human OS cells while minimizing toxic side effects. In this study, we combined CAR and DDP to treat OS, revealing that the DDP/CAR combination synergistically inhibits the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40140723
DOI: 10.1038/s41417-025-00894-9

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