Article
The genetic changes in 11p15.5-related pheochromocytomas and paragangliomas.
Endocrine-related cancer - 1 May 2025
Jenčová Pavla, Vosecká Tatiana, Štolová Lucie, Rychlá Marie, Voříšková Dagmar, Zelinka Tomáš, Musil Zdeněk, Guha Anasuya, Dušková Jaroslava, Brož Petr, Vicha Ales
Abstract excerpt
Pheochromocytomas and paragangliomas (PPGLs) are neuroendocrine tumors. The development of these tumors is associated with more than 20 genes. The aforementioned genes are subdivided into three clusters. The pseudohypoxic, kinase-signaling and Wnt clusters. The pseudohypoxic cluster is the only one that has been demonstrated to be associated with DNA methylation changes, including alterations in the 11p15.5...
Read the complete abstract on PubMedTopics
- Humans
- Pheochromocytoma
- Paraganglioma
- Adrenal Gland Neoplasms
- Female
- Male