Deciphering Pseudoendocrine Sarcoma: A Clinicopathological, Molecular, and Epigenetic Study Suggesting Biological Links With Solid Pseudopapillary Neoplasm of the Pancreas.

doi:10.1016/j.modpat.2025.100810

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Article

Deciphering Pseudoendocrine Sarcoma: A Clinicopathological, Molecular, and Epigenetic Study Suggesting Biological Links With Solid Pseudopapillary Neoplasm of the Pancreas.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Oct 2025

Fernández-Pérez Juan, Pommepuy Isabelle, Michal Michael, Michal Michal, Cleven Arjen H G, Bouvier Corinne, Gomez-Brouchet Anne, Weingertner Noelle, Papke David J, Jo Vickie Y, Garcia Jeremy, Agaimy Abbas, Azmani Rihab, Bourdon Aurelien, Hostein Isabelle, Soubeyran Isabelle, Alame Melissa, Velasco Valérie, Coindre Jean-Michel, Le Loarer François, Perret Raul Ezequiel

Abstract excerpt

Pseudoendocrine sarcoma (PS) is a recently described neoplasm of uncertain differentiation, characterized by recurrent CTNNB1 mutations, frequent paravertebral location, and a neuroendocrine-like histomorphology. In this study, we report the clinicopathologic, immunohistochemical, transcriptomic, and epigenetic findings of 12 PS cases. The tumors affected 7 men and 5 women with a median age of 66 years and were...

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Topics

Humans
Female
Male

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Aged

Pancreatic Neoplasms

Middle Aged

beta Catenin

Biomarkers, Tumor

Sarcoma

Epigenesis, Genetic

Adult

Aged, 80 and over

Mutation

Immunohistochemistry

DNA Methylation

Source

Open in PubMed

Identifiers

PMID: 40513989
DOI: 10.1016/j.modpat.2025.100810

Genes

CTNNB1
INSM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 20 Oct 2026.

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