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Pseudohypoxic pheochromocytomas and paragangliomas dominate in children

7 Mar 2021

Abstract excerpt

OBJECTIVE: Pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors that are associated with cancer predisposition syndromes in up to 80% of affected children. PPGLs can be divided into molecularly defined groups with comparable pathogenesis and biology: (1) pseudohypoxic, (2) kinase signaling, and (3) Wnt-altered. METHODS: We report the data of children and adolescents diagnosed with PPGL who...

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PMID: 33682326
DOI: 10.1002/pbc.28981

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