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What Have We Learned from Molecular Biology of Paragangliomas and Pheochromocytomas?

Endocrine pathology - 1 Mar 2021

Papathomas Thomas G, Suurd Diederik P D, Pacak Karel, Tischler Arthur S, Vriens Menno R, Lam Alfred K, de Krijger Ronald R

Abstract excerpt

Recent advances in molecular genetics and genomics have led to increased understanding of the aetiopathogenesis of pheochromocytomas and paragangliomas (PPGLs). Thus, pan-genomic studies now provide a comprehensive integrated genomic analysis of PPGLs into distinct molecularly defined subtypes concordant with tumour genotypes. In addition, new embryological discoveries have refined the concept of how normal...

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PMID: 33433885
DOI: 10.1007/s12022-020-09658-7

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