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Article

Generalizability of tau and amyloid plasma biomarkers in Alzheimer's disease cohorts of diverse genetic ancestries

1 Mar 2025

Abstract excerpt

INTRODUCTION: Plasma phosphorylated threonine 181 of tau (pTau181) and amyloid beta (Aβ) are biomarkers for differential diagnosis and preclinical detection of Alzheimer disease (AD). Given differences in AD risk across diverse populations, the generalizability of existing biomarker data is not assured. METHODS: In 2086 individuals of diverse genetic ancestries (African American, Caribbean Hispanic, and...

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PMID: 40133765
DOI: 10.1002/alz.14367

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