Article

Active and Passive Immunization of Syrian Hamsters with An Attenuated SARS-CoV-2 Protects against New Variants of Concern

2022-11-11

Abstract excerpt

<title>Abstract</title> <p>Detection of secretory antibodies in the airway is highly desirable when evaluating mucosal protection by a vaccine against a respiratory virus like the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We show that a single intranasal delivery of an attenuated SARS-CoV-2 (Nsp1-K164A/H165A) induced both mucosal and systemic IgA and IgG in Syrian hamsters. Interestingly, eith...

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Literature Corpus work: 521fade2-ee8f-5aa1-9033-78b20ed6f6eb
DOI: 10.21203/rs.3.rs-2227555/v1

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