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Article

A model of Hill-Robertson interference caused by purifying selection in a nonrecombining genome.

Genetics - 8 May 2025

Becher Hannes, Charlesworth Brian

Abstract excerpt

A new approach to modeling the effects of Hill-Robertson interference on levels of adaptation and patterns of variability in a nonrecombining genome or genomic region is described. The model assumes a set of L diallelic sites subject to reversible mutations between beneficial and deleterious alleles, with the same selection coefficient at each site. The assumption of reversibility allows the system to reach a...

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Identifiers

PMID: 40120130
DOI: 10.1093/genetics/iyaf048
PMCID: PMC12059647

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