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Article

Enhanced α2-3–linked sialylation determines the extended half-life of CHO-rVWF

18 Mar 2025

Abstract excerpt

ABSTRACT: The half-life of recombinant human von Willebrand factor (rVWF) expressed in CHO cells (CHO-rVWF; Vonicog alfa; and Vonvendi/Veyvondi) is significantly longer than that of plasma-derived VWF (pdVWF). This finding is intriguing because CHO cells do not generate α2-6 sialylation, which constitutes the majority of human pdVWF sialylation. We hypothesized that glycan differences might regulate the longer...

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PMID: 40101144
DOI: 10.1182/blood.2024027038

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