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Genome engineering of induced pluripotent stem cells to manufacture natural killer cell therapies

16 Jun 2020

Abstract excerpt

Natural killer (NK) cells play a crucial role in host immunity by detecting cells that downregulate MHC class I presentation and upregulate stress ligands, as commonly seen in cancers. Current NK therapies using primary NK cells are prone to manufacturing issues related to expansion and storage. Alternative cell sources utilizing immortalized NK cell lines require irradiation and are dependent on systemic IL-2...

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PMID: 32546200
DOI: 10.1186/s13287-020-01741-4

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