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Article

Genomic characteristics and prognostic correlations in Chinese multiple myeloma patients.

BMC medical genomics - 14 Mar 2025

Chen Xi, Luo Tianchen, Zhang Wenhui, Wang Sheng, Zhu Mengxuan, He Haiyan, Liu Jin, Lu Jing, Qiang Wanting, Jia Yanchun, Hou Nan, Zhao Xuenan, Zhang Shan, Li Jing, Du Juan

Abstract excerpt

BACKGROUND: Multiple myeloma (MM) is a hematologic malignancy characterized by the proliferation of abnormal clonal plasma cells in the bone marrow. The heterogeneity in Chinese MM populations remains underexplored. METHODS: We conducted whole-exome sequencing (WES) on 241 tumor samples, complemented by RNA sequencing (RNA-seq) on 131 samples from 212 Chinese MM patients. RESULTS: We identified a novel mutational...

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Identifiers

PMID: 40087669
DOI: 10.1186/s12920-025-02116-5
PMCID: PMC11907858

Genes

OBSCN
RB1
CACNA1H
HSPG2
IGLL5
NFKBIA
TTN
UBR5

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