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Transcriptomic and proteo-metabolic determinants of the grading system in clear cell renal cell carcinoma

13 Mar 2025

Abstract excerpt

BACKGROUND: Pathological grade is a morphological parameter of clear cell-renal cell carcinoma (ccRCC) and an independent predictor of cancer-specific survival. The aim of this study was to identify grade-dependent metabolic signatures and corresponding gene and protein expression changes that connect variations in cancer metabolism with nuclear grade, especially in high-grade tumors. METHODS: Forty ccRCC samples...

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PMID: 40082108
DOI: 10.1016/j.urolonc.2025.02.016

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