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Article

An Integrated Metabolic Atlas of Clear Cell Renal Cell Carcinoma.

Cancer cell - 11 Jan 2016

Hakimi A Ari, Reznik Ed, Lee Chung-Han, Creighton Chad J, Brannon A Rose, Luna Augustin, Aksoy B Arman, Liu Eric Minwei, Shen Ronglai, Lee William, Chen Yang, Stirdivant Steve M, Russo Paul, Chen Ying Bei, Tickoo Satish K, Reuter Victor E, Cheng Emily H, Sander Chris, Hsieh James J

Abstract excerpt

Dysregulated metabolism is a hallmark of cancer, manifested through alterations in metabolites. We performed metabolomic profiling on 138 matched clear cell renal cell carcinoma (ccRCC)/normal tissue pairs and found that ccRCC is characterized by broad shifts in central carbon metabolism, one-carbon metabolism, and antioxidant response. Tumor progression and metastasis were associated with metabolite increases in...

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Identifiers

PMID: 26766592
DOI: 10.1016/j.ccell.2015.12.004
PMCID: PMC4809063

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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