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WBP1 regulates mitochondrial function and ferroptosis to modulate chemoresistance in colorectal cancer

12 Mar 2025

Abstract excerpt

Chemoresistance continues to pose a significant challenge in managing colorectal cancer (CRC), resulting in unfavorable outcomes for patients. Recent findings indicate that ferroptosis, an innovative type of regulated cell death, might influence chemoresistance. In this research, we explored how WW domain-binding protein 1 (WBP1) affects mitochondrial function, cell growth, ferroptosis, and chemoresistance in CRC...

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PMID: 40075333
DOI: 10.1186/s10020-025-01151-3

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