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Article

The Compensatory Effect of S375F on S371F Is Vital for Maintaining the Infectivity of SARS-CoV-2 Omicron Variants.

Journal of medical virology - 1 Mar 2025

Liu Shuo, Liu Pan, Lu Qiong, Shen Yanru, Zhang Li, Liang Ziteng, Yu Yuanling, Huang Weijin, Wang Youchun

Abstract excerpt

The emergence of Omicron variants dramatically changed the transmission rate and infection characteristics compared to previously prevalent strains, primarily due to spike protein mutations. However, the impact of individual mutations remained unclear. Here, we used virus-like particle (VLP) pseudotyped to investigate the functional contributions by 12 common mutations in the spike protein. We found that the...

Read the complete abstract on PubMed

Topics

SARS-CoV-2
Spike Glycoprotein, Coronavirus
Humans
COVID-19
Angiotensin-Converting Enzyme 2
Molecular Dynamics Simulation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Mutation

Antibodies, Neutralizing

Antibodies, Monoclonal

Antibodies, Viral

Source

Open in PubMed Open full text

Identifiers

PMID: 40062404
DOI: 10.1002/jmv.70242
PMCID: PMC11891949

Genes

ACE2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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