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The mitochondrial fission factor FIS1 promotes stemness of human lung cancer stem cells via mitophagy

3 Jun 2021

Abstract excerpt

Mitophagy, a form of autophagy, plays a role in cancer development, progression and recurrence. Cancer stem cells (CSCs) also play a key role in these processes, although it not known whether mitophagy can regulate the stemness of CSCs. Here, we employed the A549-SD human non-small cell lung adenocarcinoma CSC model that we have developed and characterized to investigate the effect of mitophagy on the stemness of...

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PMID: 34051059
DOI: 10.1002/2211-5463.13207

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