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UK-based clinical testing programme for somatic and germline BRCA1/2, ATM and CDK12 mutations in prostate cancer: first results

1 Jan 2025

Abstract excerpt

Objective Germline BRCA2 pathogenic variants (PVs) are known to cause ~4% of prostate cancer, but other homologous repair genes, BRCA1, ATM, PALB2 and Lynch syndrome genes are also involved. Our objective was to assess the contribution of germline and somatic gene variants to prostate cancer. Methods and analysis We reviewed germline/tumour DNA testing from 450 localised or metastatic prostate cancer cases in NW...

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PMID: 40046829
DOI: 10.1136/bmjonc-2024-000592

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