Article
Cell-free DNA from bile outperformed plasma as a potential alternative to tissue biopsy in biliary tract cancer.
ESMO open - 1 Dec 2021
Gou Q, Zhang C Z, Sun Z H, Wu L G, Chen Y, Mo Z Q, Mai Q C, He J, Zhou Z X, Shi F, Cui W, Zou W, Lv L, Zhuang W H, Xu R D, Li W K, Zhang J, Du H W, Xiang J X, Wang H Z, Hou T, Li S T, Li Y, Chen X M, Zhou Z J
Abstract excerpt
BACKGROUND: Biliary tract cancers (BTCs) are rare and highly heterogenous malignant neoplasms. Because obtaining BTC tissues is challenging, the purpose of this study was to explore the potential roles of bile as a liquid biopsy medium in patients with BTC. PATIENTS AND METHODS: Sixty-nine consecutive patients with suspected BTC were prospectively enrolled in this study. Capture-based targeted sequencing was...
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