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Article

Dynamic Monitoring of Circulating Tumor DNA to Predict the Risk of Non In Situ Recurrence of Postoperative Glioma: A Prospective Cohort Study.

Cancer medicine - 1 Mar 2025

Guo Guangzhong, Zhang Ziyue, Zhang Jiubing, Wang Dayang, Xu Sensen, Wu Shuang, Deng Kaiyuan, Bu Yage, Sheng Zhiyuan, Yu Jinliang, Gao Yushuai, Yan Zhaoyue, Zhao Ruijiao, Wang Meiyun, Li Tianxiao, Bu Xingyao

Abstract excerpt

BACKGROUND: Glioma recurrence can be divided into in situ recurrence and non-in situ recurrence, and the mutation evolution of gliomas with different recurrence patterns is still unknown. We used sequential sequencing of circulating tumor DNA (ctDNA) to compare the somatic mutation profile and clonal evolution of gliomas with different recurrence patterns. To investigate the value of ctDNA in predicting early...

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Identifiers

PMID: 40022576
DOI: 10.1002/cam4.70733
PMCID: PMC11871513

Genes

CHEK2
EGFR
MAF
MUC16
NF1
TP53

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