Article
Elevated Tumor Mutation Burden in Cancer Patients with Underlying HIV Infection: Data from the Oncology Research Information Exchange Network (ORIEN).
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 2 May 2025
Coghill Anna E, Van Bibber Nathan, Baiocchi Robert A, Arnold Susanne M, Riedlinger Gregory, Schneider Bryan P, Zhang Yonghong, Suneja Gita, Gomez Fontela Miguel, Abate-Daga Daniel, Teer Jamie K
Abstract excerpt
BACKGROUND: People living with HIV (PWH) have improved life expectancy because of effective human immunodeficiency virus (HIV) therapy but still experience immune impairment (e.g., altered CD4/CD8 T cells). We hypothesized that tumors diagnosed in PWH would have distinct molecular features. METHODS: We utilized whole-exome sequencing of paired tumor and germline DNA and RNA from 229 patients with cancer enrolled...
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