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Article

A single residue in domain II of envelope protein of yellow fever virus is critical for neutralization sensitivity.

Journal of virology - 15 Apr 2025

Lou Ya-Nan, Sun Meng-Xu, Li Kai, Xiong Xiao-Chuan, Zhou Chao, Cao Tian-Shu, Li Xiao-Feng, Qin Cheng-Feng

Abstract excerpt

The live-attenuated yellow fever (YF) vaccine strain 17D (referred to as YF-17D) is the only commercially available vaccine against YF. Recent yellow fever virus (YFV) isolates of South American genotype I (SAI) showed reduced sensitivity to sera from individuals vaccinated with YF-17D. However, the underlying mechanisms remain inadequately elucidated. Here we conducted a screening of a panel of amino acid...

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Share to Antibodies, Neutralizing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40019254
DOI: 10.1128/jvi.01770-24
PMCID: PMC11998516

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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