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Impact of yellow fever virus envelope protein on wild-type and vaccine epitopes and tissue tropism

23 Mar 2022

Abstract excerpt

The envelope (E) protein of flaviviruses is functionally associated with viral tissue tropism and pathogenicity. For yellow fever virus (YFV), viscerotropic disease primarily involving the liver is pathognomonic for wild-type (WT) infection. In contrast, the live-attenuated vaccine (LAV) strain 17D does not cause viscerotropic disease and reversion to virulence is associated with neurotropic disease. The...

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PMID: 35322047
DOI: 10.1038/s41541-022-00460-6

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