Genotype-specific features reduce the susceptibility of South American yellow fever virus strains to vaccine-induced antibodies.

doi:10.1016/j.chom.2021.12.009

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Genotype-specific features reduce the susceptibility of South American yellow fever virus strains to vaccine-induced antibodies.

Cell host & microbe - 9 Feb 2022

Haslwanter Denise, Lasso Gorka, Wec Anna Z, Furtado Nathália Dias, Raphael Lidiane Menezes Souza, Tse Alexandra L, Sun Yan, Stransky Stephanie, Pedreño-Lopez Núria, Correia Carolina Argondizo, Bornholdt Zachary A, Sakharkar Mrunal, Avelino-Silva Vivian I, Moyer Crystal L, Watkins David I, Kallas Esper G, Sidoli Simone, Walker Laura M, Bonaldo Myrna C, Chandran Kartik

Abstract excerpt

The resurgence of yellow fever in South America has prompted vaccination against the etiologic agent, yellow fever virus (YFV). Current vaccines are based on a live-attenuated YF-17D virus derived from a virulent African isolate. The capacity of these vaccines to induce neutralizing antibodies against the vaccine strain is used as a surrogate for protection. However, the sensitivity of genetically distinct South...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Viral

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Brazil

Share to Genotype

Share to Mosquito-borne diseases and control

Share to Vaccines, Attenuated

Share to Viral Infections and Vectors

Share to Yellow Fever

Share to Yellow fever virus

Source

Open in PubMed Open full text

Identifiers

PMID: 34998466
DOI: 10.1016/j.chom.2021.12.009
PMCID: PMC10067022

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genotype-specific features reduce the susceptibility of South American yellow fever virus strains to vaccine-induced antibodies.PMID 34998466Read ↗

New Insights Into an Old Vaccine: Potency and Breadth of Neutralizing Antibodies Elicited by Yellow Fever Vaccine 17D Are Boosted by Heterologous Orthoflavivirus Infection.Semantic proximity Read ↗

A single residue in domain II of envelope protein of yellow fever virus is critical for neutralization sensitivity.Semantic proximity Read ↗

Mutation in a 17D-204 Vaccine Substrain-Specific Envelope Protein Epitope Alters the Pathogenesis of Yellow Fever Virus in MiceSemantic proximity Read ↗

Genomic and structural features of the yellow fever virus from the 2016-2017 Brazilian outbreak.Semantic proximity Read ↗

Prior flavivirus immunity skews the yellow fever vaccine response to expand cross-reactive antibodies with increased risk of antibody dependent enhancement of Zika and dengue virus infectionSemantic proximity Read ↗

Identification of Novel Yellow Fever Class II Epitopes in YF-17D Vaccinees.Semantic proximity Read ↗

Yellow fever virus: genetic and phenotypic diversity and implications for detection, prevention and therapy.Semantic proximity Read ↗

The uniqueness of the Brazilian Yellow Fever Virus. Are the vaccines less effective against it?Semantic proximity Read ↗

Impact of yellow fever virus envelope protein on wild-type and vaccine epitopes and tissue tropismSemantic proximity Read ↗

E Protein Domain III Determinants of Yellow Fever Virus 17D Vaccine Strain Enhance Binding to Glycosaminoglycans, Impede Virus Spread, and Attenuate VirulenceSemantic proximity Read ↗

Broad neutralization of wild-type dengue virus isolates following immunization in monkeys with a tetravalent dengue vaccine based on chimeric yellow fever 17D/dengue viruses.Semantic proximity Read ↗

Genetic Characterization of Yellow Fever Virus Strain JSS, the Original South American Strain.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.