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Article

Computational phenotyping of brain-behavior dynamics underlying approach-avoidance conflict in major depressive disorder.

PLoS computational biology - 1 May 2021

Pedersen Mads L, Ironside Maria, Amemori Ken-Ichi, McGrath Callie L, Kang Min S, Graybiel Ann M, Pizzagalli Diego A, Frank Michael J

Abstract excerpt

Adaptive behavior requires balancing approach and avoidance based on the rewarding and aversive consequences of actions. Imbalances in this evaluation are thought to characterize mood disorders such as major depressive disorder (MDD). We present a novel application of the drift diffusion model (DDM) suited to quantify how offers of reward and aversiveness, and neural correlates thereof, are dynamically integrated...

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Open in PubMed Open full text

Identifiers

PMID: 33970903
DOI: 10.1371/journal.pcbi.1008955
PMCID: PMC8136861

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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