Timing of menarche and menopause and epigenetic aging among U.S. adults: results from the National Health and Nutrition Examination Survey 1999–2002

Abstract excerpt

Abstract Reproductive aging, including timing of menarche and menopause, influences long-term morbidity and mortality in women, yet underlying biological mechanisms remain poorly understood. Using DNA methylation-based biomarkers, we assessed associations of age at menarche ( N = 1,033) and menopause ( N = 658) with epigenetic aging in a nationally representative sample of women ≥ 50 years. Later age at menopause...

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